Ex Parte LI et al - Page 10




              Appeal No. 2005-1516                                                                                     
              Application No. 09/182,645                                                                               
              obviousness rejection.  These noted deficiencies in Wang, Ning and Tanuma 1 and 2                        
              are not overcome by their further combination with Wen and Kim.   In our view the                        
              examiner has not provided a clear reason, suggestion or motivation to combine Tanuma                     
              1 and 2, disclosing a purified lignin glycoside for the treatment of cancer with Wang,                   
              describing a tea for the treatment of diabetes, or Ning, a tea for the treatment of                      
              ischemia.                                                                                                
                     The examiner argues both Kim and Wen teach that a ginseng extract is useful for                   
              treating ischemia and/or reperfusion injury.  Paper No. 29, Non-final, page 7.  Wen                      
              describes the effects of red ginseng powder (RGP), crude ginseng saponin (CGS),                          
              crude ginseng non-saponin (CGNS), ginsenoside (Rb1) ginsenoside Rg1 and                                  
              ginsenoside Ro on response latency of neurons in ischemic gerbils.  Page 17.  The                        
              examiner has not indicated or shown that any of the ginsenosides or crude ginseng                        
              products of Wen contain lignin glycoside.  The examiner has not pointed out any                          
              teaching or suggestion in the art to use the lignin glycoside taught by Tanuma 1 and 2 in                
              Wen’s patients.  Nor has the examiner indicated how Wen makes up for any of the                          
              deficiencies noted in the combination of Wang, Ning and Tanuma 1 and 2.                                  
                     We do not find on the record before us the examiner has made out a prima facie                    
              case of obviousness in view of Kim for reasons similar to those cited for Wen.  In view                  
              of the above, the rejection of the claims over Wang, Ning, Tanuma 1 and 2 in further                     
              view of Kim and Wen is reversed.                                                                         



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