Ex Parte Brookes - Page 8


                  Appeal No.  2006-0258                                                              Page 8                    
                  Application No.  09/755,747                                                                                  
                          This leaves Exhibits 7 and 8.  As appellant explains (Brief, bridging                                
                  paragraph, pages 9-10 and 11), as a result of from “a corporate merger/                                      
                  restructuring, Boehringer-Mannheim was renamed Roche Molecular                                               
                  Biochemicals on March 5, 1998 (see Exhibit 8 . . .), which company was then                                  
                  subsequently re-named Roche Applied Science.  The product formerly marketed                                  
                  under the Boehringer-Mannheim name is now sold by Roche Applied Science                                      
                  under the trademark StreptaWell (see Exhibit 7).”                                                            
                          Upon review of Exhibits 7 and 8, we find that like Exhibits 4-6, Exhibits 7                          
                  and 8 do not disclose whether the plates contain a streptavidin monolayer.                                   
                  Accordingly, we do not find Exhibits 7 and 8 persuasive with regard to the issue                             
                  before us.  See also Answer, page 16, where the examiner finds that these                                    
                  Exhibits “do not directly inform this analysis.”                                                             
                          Having found that Exhibits 1-8 do not resolve the issue before us, we                                
                  move to the remaining two pieces of evidence that appellant relies upon to                                   
                  support his position - the Strohner Declaration, and the Jordan reference.                                   
                  According to Strohner (Strohner Declaration, paragraph 2), “[r]egardless of                                  
                  coating procedure details, immobilization of streptavidin onto solid-surfaces (such                          
                  as plastic microtiter plates and membranes) will result in a reactive streptavidin                           
                  monolayer.  DNA molecules which are bound to this reactive streptavidin                                      
                  monolayer will inevitably form a superimposed DNA monolayer.”  While the                                     
                  examiner asserts (Answer, page 17), that weight was given to the Strohner                                    
                  Declaration, the opinion expressed therein is rebutted by the Jordan reference.                              

                                                                                                                               
                  Assembled Monolayer.”                                                                                        





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