Ex Parte Lupski et al - Page 6


               Appeal No.  2006-0298                                                 Page 6                 
               Application No.  10/021,955                                                                  

                      Thus, even when the rejection mentioned the elected subject matter, the               
               analysis of the rejection made under 35 U.S.C. § 112, first paragraph, for lack of           
               enablement, was not limited to the elected subject matter.                                   
                      Upon return of the application, the examiner should reconsider the                    
               rejection in view of the restriction requirement and the election of species.  If the        
               examiner is withdrawing the restriction requirement and the election of species,             
               that fact should be stated for the record.  If the examiner is not withdrawing the           
               restriction requirement and the election of species, the analysis accompanying               
               the rejection should be limited to that subject matter, i.e., the claims as they read        
               on SEQ ID NO. 76 and 247∆C.  In making that rejection, the record should                     
               establish the relationship between SEQ ID NO. 76 and the other claimed SEQ ID                
               Nos, and why any enablement provided for the other SEQ ID NO.s does not                      
               apply to the elected SEQ ID NO.  The same should also be done for the elected                
               species 247∆C.                                                                               
                      Finally, the examiner’s analysis is focused on a method as set forth in               
               claim 1, and does not adequately address the methods as set forth in claims 35               
               and 49.                                                                                      
                      Claim 1 is drawn to a method of diagnosing myelinopathy in an individual.             
               Claim 35 is drawn to a method of detecting the presence or absence of a                      
               mutation associated with a myelinopathy, and claim 49 is drawn to a method of                
               detecting a polymorphism or a mutation a periaxin polynucleotide of an individual.           
               All that is required by those two claim is comparison of the test nucleic acid               
               comprising a periaxin polynucleotide to a wild-type periaxin polynucleotide, and             





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