Ex Parte de Paoli Ambrosi - Page 8


                   Appeal No.  2006-0729                                                                Page 8                    
                   Application No.  10/322,566                                                                                    
                   Obviousness:                                                                                                   
                          Claims 12-23 stand rejected under 35 U.S.C. § 103 as being unpatentable                                 
                   over Chen.  According to the examiner (Answer, page 6), Chen teach, inter alia,                                
                   a composition for topical use comprising ethyl linoleate and triethyl citrate.                                 
                   However, as appellant points out (Brief, page 34), Chen’s invention “relates to                                
                   pharmaceutical compositions and methods for improved solubilization of                                         
                   triglycerides and improved delivery of therapeutic agents.”  Chen, abstract.  In                               
                   this regard, we note that Chen’s compositions include “a triglyceride and a                                    
                   carrier,” wherein the “carrier includes at least two surfactants, at least one of                              
                   which is a hydrophilic surfactant.”  Chen, column 5, lines 10-13.                                              
                          With regard to the components recited in appellant’s claimed invention,                                 
                   Chen discloses ethyl linoleate as an example of a hydrophobic surfactant that                                  
                   may be included in the carrier.  Chen, column 22, lines 22-40.   In addition, Chen                             
                   discloses triethylcitrate as an example of a solubilizer that may be optionally                                
                   included in the composition to “enhance the solubility of the therapeutic agent[ ]3                            
                   or the triglyceride.”  Chen, column 33, line 62 – column 34, line 18.  Therefore, as                           
                   we understand it, Chen teaches a triglyceride composition that comprises, inter                                
                   alia, ethyl linoleate and triethylcitrate.                                                                     
                          As discussed a triglyceride would affect the basic and novel properties of                              
                   appellant’s claimed invention, and is therefore expressly excluded from                                        
                   appellant’s claimed composition by use of the transitional phrase “consisting                                  
                   essentially of.”  Since, Chen’s compositions comprise triglycerides, we reverse                                
                                                                                                                                  
                   3 According to Chen (abstract), a “therapeutic agent can be incorporated into the [triglyceride]               
                   compositions, or can be co-administered with the [triglyceride] composition.”                                  





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