Ex Parte Desponds et al - Page 2


              Appeal No. 2006-2428                                                                      Page 2                 
              Application No. 10/362,500                                                                                       

              making a thiazole derivative is “described in the literature” in which a chlorinating agent                      
              is reacted with a compound of formula (II)                                                                       





              where X is a leaving group, to form the compound of formula (III)                                                




              and then reacting the compound of formula (III) with a compound of the formula (IV)                              






              to yield a thiazole derivative of formula (I)                                                                    






              where, in each of the above formulas,                                                                            
                      Q is CH or N;                                                                                            
                      Y is NO2 or CN;                                                                                          
                      Z is CHR3, O, NR3 or S;                                                                                  
                      R1 and R2 either are each independently of the other hydrogen or C1-C8 alkyl                             








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