Ex Parte Zhong et al - Page 9


            Appeal No. 2006-2826                                                        Page 9              
            Application No. 09/993,907                                                                      

                   The hydrogel and devices disclosed by Weissleder were stated by the Examiner             
            to meet the structural limitations set forth in claim 1.  Answer, pages 3-4.  Because           
            these limitations were met, the Examiner properly reasoned that the degree of hydrogel          
            cross-linking was sufficient to cause it to be visible when under MRI.                          
                   Appellants challenged the rejection, arguing that Weissleder’s purpose in cross-         
            linking the hydrogel is “to ensure [its] insolubility” in order to load it with the magnetically
            active labels which are detectable by MRI.”  Brief, page 8, paragraphs 3-6.  Once               
            labeled, imaging of the hydrogel is achieved because of the presence of the label, not          
            the hydrogel’s degree of cross-linking.  Id., page 9.                                           
                   We are not persuaded by this argument.  The fact that a paramagnetic label was           
            used by Weissleder to visualize the device does not preclude the cross-linked gel from          
            having been sufficient by itself to have made the device visible to MRI.  Weissleder’s          
            purpose is not relevant to the question of whether the hydrogel-coated device would             
            possess the claimed features, albeit unrecognized at the time.                                  
                   For the reasons discussed previously, we conclude that the Examiner has                  
            provided sufficient evidence to establish a case of prima facie anticipation, which             
            Appellants have not overcome.  This rejection is affirmed.                                      
















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