Ex Parte Leiden et al - Page 7


                 Appeal 2006-1971                                                                                    
                 Application 10/144,224                                                                              

            1                     122, 124, and 126 is approximately 2mm.  (Specification                            
            2                     19).                                                                               
            3           4.   Steuer is directed to non-invasive monitoring of hematocrit                             
            4                     and other blood parameters of a patient (col. 1, ll. 14-17).                       
            5           5. The sensor-emitter separation distances of Steuer are                                     
            6                     important to provide a detection region in the subdermis 12.                       
            7                     The determination of optimum sensor 3 separation and                               
            8                     aperture 8 sizes is done empirically.  Minimum sensor                              
            9                     separation and aperture diameters can be established.  (col.                       
           10                     12, ll. 17-30).                                                                    
           11           6. Fig. 1B of Steuer illustrates a reflective mode system where                              
           12                     emitters 1 and    photodiodes 3 are on the same side of the                        
           13                     patient's finger.                                                                  
           14           7. Soller is directed to a non-invasive optical and mathematical                             
           15                     method of measuring hematocrit.  (col. 1, ll. 44-46).                              
           16           8. Figs. 13 A and B of Soller describe a hematocrit measuring                                
           17                     device having a separation distance between the LEDs 804                           
           18                     and the detector 805 of 2-4mm.  (col. 18, l. 66 to col. 19,                        
           19                     l. 3).                                                                             
           20           9. In addition, Soller describes that a separation of 1-5mm                                  
           21                     between the illuminating fibers and receiving fibers                               
           22                     facilitates adequate depth penetration into the tissue.  (col.                     
           23                     21, ll. 19-24).                                                                    
           24           10. Arakaki is directed to an optical method for non-invasive                                
           25                     measurement of muscle tissue oxygen saturation to calculate                        

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