Appeal 2006-2372
Application 10/854,708
1. A method for measuring platelet function comprising:
obtaining a baseline count of platelets in a sample comprising platelets
in a liquid medium obtained from a physiological source of the platelets,
wherein the sample is devoid of an effective amount of an agent which
interferes with platelet function;
subsequently adding an activation agonist to the sample;
allowing activatable platelets in the sample to activate;
obtaining a count of the unactivated platelets in the sample after
activation of the activatable platelets;
determining the difference between the baseline count of platelets in
the sample before adding the activation agonist and the count of unactivated
platelets in the sample;
wherein the difference is a measure of the activity of the platelets in
the original sample; and
wherein the sample prior to the addition of the activation agonist
includes D-phenylalanyl-L-prolyl-L-arginine chloromethyl ketone (PPCAK
[sic, PPACK]) as an anti-coagulant.
6. The method of claim 1, wherein the activation-agonist is in solid
form and wherein the activation agonist is added in solid form to the sample.
The Examiner relies on the following prior art references to show
unpatentability:
Brady US 6,410,337 B1 Jun. 25, 2002
Jennings WO 2004/036226 A1 Apr. 29, 2004
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