Ex Parte Totterman et al - Page 3

               Appeal 2006-2514                                                                             
               Application 10/233,562                                                                       
                      Appellants contend that one of ordinary skill in the art would not have               
               found the motivation to combine the applied references to achieve the                        
               presently claimed invention because Gilhuijs is concerned with breast                        
               tumors whereas Kennedy is concerned with the brain (Br. 4-6).                                
                      We affirm.                                                                            
                                                  ISSUE                                                     
                      Have the Appellants shown that the skilled artisan would not have                     
               combined the teachings of the applied references to arrive at the claimed                    
               subject matter?                                                                              
                                          FINDINGS OF FACT                                                  
                      Appellants’ invention takes a three-dimensional image of an organ                     
               (e.g., the brain or nervous system), and identifies at least one biomarker (Fig.             
               1).  A quantitative measurement is made of the biomarker, and the results are                
               stored in a storage medium (Figs. 1 and 4).                                                  
                      In an appeal of Appellants’ related application Serial Number                         
               10/241,763 (Appeal Number 2005-2414), the Board found the following                          
               facts about the teachings of Gilhuijs in a decision dated October 27, 2005:                  
                            Notwithstanding the examiner’s mixing of volume                                 
                            and surface, we find that the examiner’s findings                               
                            of fact (answer, pages 3 and 4) also points out                                 
                            tumor extent/shape (column 1, lines 14 through 16)                              
                            as a biomarker.  Gilhuijs derives “at least one                                 
                            quantitative measurement of the at least one                                    
                            biomarker” by “quantification of the tumor                                      
                            surface” (column 6, lines 61 through 64).  We                                   
                            additionally find that the “radius” is also a                                   
                            quantitative measurement of the extent/shape                                    
                            tumor biomarker and is also a quantitative                                      
                            measurement of the malignant lesion with a                                      


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