Ex Parte Totterman et al - Page 5

               Appeal 2006-2514                                                                             
               Application 10/233,562                                                                       
                      In sustaining a multiple reference rejection under 35 U.S.C. § 103(a),                
               the Board may rely on one reference alone without designating it as a new                    
               ground of rejection.  In re Bush, 296 F.2d 491, 496, 131 USPQ 263, 266-67                    
               (CCPA 1961); In re Boyer, 363 F.2d 455, 458 n.2, 150 USPQ 441, 444 n.2                       
               (CCPA 1966).                                                                                 
                                               ANALYSIS                                                     
                      As our findings supra indicate, the limitations of claims 1, 2, 4, 6 to 8,            
               10 to 13, 15, 17, 18, 20, 21 and 23 read directly on the brain and                           
               neurological analysis teachings of Kennedy.  The breast analysis teachings                   
               of Gilhuijs are merely cumulative to teachings already present in Kennedy.                   
                      With respect to claims 3, 5, 14 and 16, we hold that the skilled artisan              
               would have used the statistical segmentation teachings of Gilhuijs to aid in                 
               the identification of a tumor in surrounding tissue in Kennedy.                              
                      To the extent that Appellants’ disclosed and claimed biomarker                        
               comprises a “higher-order measurement” as set forth in claims 22 and 24, we                  
               hold that Kennedy’s biomarker is likewise a “higher-order measurement.”                      
                      Turning lastly to claims 9 and 19, Appellants have not presented any                  
               patentability arguments for these claims apart from the arguments presented                  
               for the independent claims on appeal.                                                        
                                         CONCLUSION OF LAW                                                  
                      The obviousness rejection of claims 1, 2, 4, 6 to 8, 10 to 13, 15, 17,                
               18, 20, 21 and 23 is sustained based on the teachings of Kennedy.  The                       
               obviousness rejections of claims 3, 5, 9, 14, 16, 19, 22 and 24 are sustained                
               based upon the teachings and suggestions of the applied references.                          




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