Ex Parte Yang et al - Page 6

                 Appeal No. 2006-2654                                                                                                   
                 Application No. 10/100,276                                                                                             

                        Having interpreted claim 1, we turn to the issue of whether the cited                                           
                 prior art patents anticipate it.  The Examiner contends that the claimed                                               
                 apparatus is anticipated by a multi-channel laminar flow device which is                                               
                 described in each of Yager, Weigl, and Malmqvist.  The basis of the                                                    
                 rejection is the same for all three patents.  We choose Yager as                                                       
                 representative.  According to Yager,                                                                                   
                        [t]he extraction system of this invention in simplest concept is                                                
                        illustrated by a diffusion extraction device comprising                                                         
                        microchannels in the shape of an “H”.  A mixture of particles                                                   
                        suspended in a sample stream enters the extraction                                                              
                        channel . . . from one of the arms, e.g., the top left, and an                                                  
                        extraction stream (a dilution stream) enters from the bottom                                                    
                        left. . . . While the streams are in adjacent laminar flow in the                                               
                        extraction channel, particles having a greater diffusion                                                        
                        coefficient (smaller particles such as albumin, sugars and small                                                
                        ions) have time to diffuse into the extraction stream, while the                                                
                        larger particles (e.g., blood cells) remain in the sample stream.                                               
                 Col. 4, ll. 47-63.                                                                                                     
                        Yager states that “fluid barrier” is formed in the extraction channel by                                        
                 the two streams in laminar flow.  Col. 14, ll. 16-36.  The Examiner asserts                                            
                 that the “fluid barrier” is a “wall defining a dam” as required by claim 1.                                            
                 Answer 8.  We do not agree.  As we have interpreted it, a “wall defining a                                             
                 dam” is an integral and structural feature of the claimed apparatus.  The                                              
                 “fluid barrier” described in Yager is not a structural feature of the apparatus,                                       
                 but is formed by two fluids streams in laminar flow with each other in the                                             
                 same channel when the apparatus is in use.                                                                             





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