Ex Parte NEERVEN - Page 13

                 Appeal 2007-1070                                                                                      
                 Application 09/467,901                                                                                

                        Conclusion                                                                                     
                        For the foregoing reasons, we affirm the rejection of claim 1 as                               
                 obvious over Johansen in view of Johnson and Frank (Answer 3).  Claims                                
                 2-5, 8-14, 16, and 21-23 fall with claim 1 because separate arguments for                             
                 their patentability were not provided.                                                                

                 Obviousness of claims 6 and 17-20                                                                     
                        Claims 6 and 17-20 stand rejected under 35 U.S.C. § 103 as obvious                             
                 over Johansen in view of Johnson and Frank, and further in view of Arnold                             
                 (Answer 7).                                                                                           
                        Claim 6 further requires adding a label after a first separation step                          
                 followed by a second separation step to separate non-complexed label from                             
                 the labeled complex (Br. 21; Answer 7).                                                               
                        The Examiner has provided evidence that a person of ordinary skill in                          
                 the art would have reason to have combined Arnold with Johansen and                                   
                 Frank for Arnold’s known advantages (Answer 7; FF 17).                                                
                        Appellant argues that Arnold does not “cure” the “defect” in the                               
                 combination of Johansen and Frank (Br. 22).  They also argue that Arnold’s                            
                 assay differs from the claimed assay in teaching immobilized capture                                  
                 antibody (Br. 22).                                                                                    
                        [T]hus the interaction between the antibody and the ligand does                                
                        not take place freely in solution . . . [as required by claim 6].                              
                        There is no teaching in Arnold suggesting that such an assay                                   
                        could be adapted to detect antibodies let alone using an                                       
                        antibody receptor that is not immobilized to do it.                                            
                 (Br. 22.)                                                                                             


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