Ex Parte Kashima et al - Page 7

               Appeal 2007-1627                                                                            
               Application  09/870,009                                                                     

                      Appellants argue that the “nucleotide sequence added to a portion of                 
               DNA is not just any old nucleotide sequence, but instead is a nucleotide                    
               sequence that is ‘not naturally occurring’” (Reply Br. 2).  As discussed                    
               above, however, viral DNA is not naturally occurring in a host cell’s                       
               chromosomal DNA; “naturally occurring” human DNA, for example, does                         
               not include the HIV gag, pol, and env genes.                                                
                      Appellants argue, however, that the claim language requires human                    
               intervention:                                                                               
                      [T]he  nucleotide    sequence includes  [“]source  identification                    
                      information”. . . . Appellant submits that this certainly implies                    
                      some human intervention. That is, without human intervention                         
                      the [“]source” of any genetic information in a gene portion is                       
                      not an issue.                                                                        
                      Further,  the  source  identification  information  “identifies”  a                  
                      source of the genetic information in the gene portion.                               
                      Appellant again submits that this implies some human                                 
                      intervention.  That is, the source identification information is                     
                      not likely intended for identifying genetic information without                      
                      at least some human intervention . . . .                                             
                      Further, claim 5 defines DNA having a nucleotide sequence                            
                      which  is  “embedded  in”  a  portion  of  the  DNA. . . . [T]he                     
                      claimed  DNA  in  which  a  nucleotide  sequence  has  been                          
                      embedded inherently  requires  human  intervention  and  is  by                      
                      definition not naturally-occurring.                                                  
               (Reply Br. 2-3.)                                                                            
                      We disagree with Appellants’ interpretation of the claim language.                   
               As shown by Darnell, DNAs have “sources” and sequences that identify                        
               those sources even without human intervention.  Darnell also shows that                     
               DNAs from different sources (e.g., human and viral) can be mixed, and one                   

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