Appeal 2007-2864
Application 10/747,798
Hay, D. “Management of oral problems associated with cancer
treatment: radiotherapy,”
www.8.co.nz/hospitaldenistry/papers/Management_of_Oral_Problems_
Associated_with_005.htm, accessed by PTO on 10/11/06.
Lowe, B. “Abnormal Cervical Smears – a patient’s guide,”
www.medic8.com/healthguide/articles/abnormalcervicalsmear.html,
accessed by PTO on 10/11/06.
“What is a dermatologist?”
www.aad.org/public/Parentskids/KidsConnection/Whatisderm.htm, accessed
by PTO on 10/11/06.
We affirm.
BACKGROUND
According to the Specification,
Many proliferative conditions are known to be associated
with papillomaviruses. Examples include benign lesions such
as cutaneous warts and anogenital warts and premalignant
lesions such as epidermodysplasia verruciformis.
Papillomaviruses are also associated with malignant lesions
including carcinomas of the head and neck, cervix, anus, and
penis. In 1998, the American Cancer Society estimated that
60,000 Americans would be diagnosed with head and neck
cancer. HPV has been linked to 15-46% of cases and head and
neck squamous cell carcinoma (HNSCC). Patients with early
stage HNSCC or patients who are cured from advanced cancers
have a low probability of death from their primary cancer but
have a significant chance of dying from a second primary
tumor. More importantly, treatment (chemoprevention) of
high-risk populations may reduce the development of a second
primary tumor and therefore significantly improve survival.
Two chemoprevention trials using 13-cis-retinoic acid (CRA)
have demonstrated the efficacy of clinically reversing
premalignant lesions and reducing the risk of secondary
primary tumors. However, CRA is toxic, poorly tolerated and
loses its preventative effects after discontinuation of therapy.
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