Ex Parte Yoo - Page 9

                 Appeal 2007-2864                                                                                      
                 Application 10/747,798                                                                                
                 between one-third and one-half of oral squamous cell carcinoma involves                               
                 HPV infection.  Moreover, although not disclosing the results, Clayman did                            
                 test for HPV of the microdissected lesion (Slide 8 entitled “Special Protocol                         
                 Testing Summary Pre Treatment”).  Thus, in those lesions in which HPV is                              
                 involved, the growth of a papillomavirus-transformed cell would be                                    
                 inhibited.  It is unnecessary that this result was intended or recognized.                            
                        It may be that not every instance in which the claimed composition is                          
                 administered by Clayman to a hyperplastic lesion would result in                                      
                 anticipation.  But, as discussed above, HPV involvement is common in such                             
                 lesions, establishing that anticipation would necessarily result.  In Perricone                       
                 v. Medicis Pharm. Corp., 432 F.3d 1368, 1379, 77 USPQ2d 1321, 1328                                    
                 (Fed. Cir. 2005), a claim to a method of preventing sunburn damage by                                 
                 topically applying a composition to exposed skin was held to be anticipated                           
                 by a disclosure of a topical skin cream “because all skin surfaces are                                
                 susceptible to sunburn damage.”  Anticipation was based on the skin’s                                 
                 susceptibility to sunburn, not the requirement that, each time the prior art                          
                 topical cream was applied to exposed skin, sunburn was actually prevented.                            
                 Likewise, we do not find it necessary that HPV involvement be present in                              
                 every case.  It is enough that human papillomavirus infection is known to be                          
                 associated with different cancerous and precancerous conditions.  Thus, the                           
                 result would not be “occasional,” but a certainty in a certain percentage of                          
                 patients being treated using the composition required by the claimed method.                          
                        Appellant argues as to claim 4 that Clayman does not expressly or                              
                 inherently disclose the limitation “wherein the cell is a keratinocyte.”  (Br.                        
                 8.)                                                                                                   



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