Appeal No. 97-2833
Application 08/236,190
THE INVENTION
Appellant’s claimed invention is a method for managing body weight changes in
a human by administering to the human a specified amount of one or more nicotine
metabolites or pharmaceutically acceptable salts thereof. Claim 34 is illustrative and
reads as follows:
34. A therapeutic method used to manage short-term human body weight
changes through suppression of appetite or prevention of weight gain or induction of
weight loss during the initial tobacco abstinence phase in nicotine-experienced or
nicotine-naive individuals comprising of administering a nicotine metabolite or
combination of nicotine metabolites or their pharmaceutically acceptable salts thereof
to a human in need of such treatment, in an amount in the range of 1 to 100 milligrams
per kilogram of body weight of the human per day calculated as the nicotine metabolite
or combination of nicotine metabolites in the free base form that is effective to suppress
appetite, prevent weight gain or induce weight loss in an individual in the need of such
treatment.
THE REFERENCES
References relied upon by the examiner
Michaels 3,867,519 Feb. 18, 1975
Hutchinson et al. (Hutchinson) 3,870,794 Mar. 11, 1975
Abood (Abood ‘916) 4,966,916 Oct. 30, 1990
Joseph F. Borzelleca et al., “Studies on the Respiratory and Cardiovascular Effects of
(-)-Cotinine”, 137 J. Pharm. Exper. Therapeutics, 313-18 (1962) (Borzelleca).
The Health Consequences of Smoking - Nicotine Addiction, Report of the Surgeon
General 197-208 (1988) (Surgeon General’s report).
Reference relied upon by the board
Keenan 5,643,928 Jul. 1, 1997
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