Ex parte IBRAHIM et al. - Page 6



             Appeal No. 95-4321                                                                                       
             Application 07/976,241                                                                                   


             supply that which is missing from Beadle.  We agree with appellants' statements (principal               
             brief, page 11-12):                                                                                      
                    There is no suggestion in Fiehring et al. of the use of selective fermentation                    
                    to separate glucose from galactose as is required according to the Group                          
                    One claims.                                                                                       
                    There is no suggestion in Hartley et al. that it would be possible to                             
                    selectively ferment one sugar to separate it from another.                                        
                    A reasonable reading of Fiehring indicates that lactose and its decomposition                     
             products galactose and glucose are all being removed from the milk products described.                   
             Similarly, Hartley does not disclose or suggest the selective fermentation of glucose over               
             D-galactose.   To establish a prima facie case of obviousness, there must be more than                   
             the demonstrated existence of all of the components of the claimed process.  There must                  
             be some reason, suggestion, or  motivation found in the prior art whereby a person of                    
             ordinary skill in the field of the invention would make the substitutions required.  That                
             knowledge can not come  from the applicants' invention itself.   Diversitech Corp. v.                    
             Century Steps, Inc.,  850 F.2d 675, 678-79,  7 USPQ2d 1315, 1318 (Fed. Cir. 1988); In re                 
             Geiger, 815 F.2d 686, 688, 2 USPQ2d 1276, 1278 (Fed. Cir. 1987);  Interconnect                           
             Planning Corp. v. Feil, 774 F.2d 1132, 1143,  227 USPQ 543, 551 (Fed. Cir. 1985).  The                   
             extent to which such suggestion must be explicit in or may be fairly inferred from, the                  
             references, is decided on the facts of each case, in light of the prior art and its relationship         
             to the invention.  It is impermissible, however,  simply to engage in a hindsight                        
             reconstruction of the claimed inventions using applicants' claimed invention as a template               


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