Ex parte MANZ et al. - Page 8




         Appeal No. 1997-3328                                                    
         Application No. 08/226,605                                              


         how to provide a geometrically defined sample in a                      
         electrophoresis device as described in claim 19.  The claimed           
         method uses a sample composition having different                       
         electrophoretic mobilities and claim 19 requires the electric           
         field applied across the supply and drain to be held for a              
         minimum period based on the component with the slowest                  
         electrophoretic mobility.  We do not find the prior art to be           
         suggestive of this solution.                                            
              We reject the examiner's contention that maintaining the           
         electric field for the minimum time is simply an obvious art            
         recognized result-effective variable.  The cited and applied            
         prior art does not teach that the electric field across the             


         supply and drain, in the method of operating the device as              
         specified in claim 19, is a known variable.  Also, the                  
         examiner does not explain why changing, or varying, the dwell           
         time would have been obvious to either Verheggen or Harrison.           
         First, Harrison's device is so dissimilar that if the dwell             
         time were extended it is not apparent that the process of               
         claim 19 (providing a geometrically defined sample) would               
         result.  Secondly, Verheggen points to the disadvantages of             
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