Appeal No. 1997-3811 Page 6
Application No. 08/357,845
(b) introducing said racemic compound mixture
into said countercurrent chromatographic centrifuge
column thus charged with said chiral selector and
said first liquid phase; and
(c) passing a second liquid phase through said
countercurrent chromatographic centrifuge column
thus charged with said mixture, said chiral selector
and said first liquid phase, to elute said (+)
enantiomer and said (-) enantiomer from said
countercurrent chromatographic centrifuge column,
wherein said quantity is from 1 mg to 1kg.
Both Pirkle ‘440 and Pirkle ‘293 disclose a process for
separating enantiomers utilizing a chiral selector. Each of
Pirkle ‘440 and Pirkle ‘293 describe methods for separating
enantiomers using high performance liquid chromatographic
columns and enantioselective membrane transport devices with
some particularity. See, e.g., column 9, line 55 through
column 12, line 9 of Pirkle ‘440 and column 17, line 61
through column 19,
line 38 of Pirkle ‘293. Moreover, each of Pirkle ‘440 and
Pirkle ‘293 generally describe countercurrent chromatographic
devices as an alternative to the above-noted separation
devices as repeatedly noted by the examiner in the answer.
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