Appeal No. 1999-1407
Application No. 08/295,744
Claim 1 is illustrative of the subject matter on appeal and is reproduced
below:
1. A compound of the structure:
G0-G1-G2-G3
wherein:
G0 is a nucleoside, a nucleotide or an oligonucleotide;
G1 is a bivalent linking moiety;
G2 is an aryl or heteroaryl moiety; and
G3 is a nitrogen-containing heterocyclic RNA cleaving chemical
functional group having general acid/base properties.
The references relied upon by the examiner are:
Marvin H. Caruthers (Caruthers), Synthesis of Oligonucleotides and Oligonucleotide
Analogues, in ANTISENSE INHIBITORS OF GENE EXPRESSION 7-22 (J.S. Cohen ed.,
CRC press, Boca Raton, FL, 1989)
Mitchell et al. (Mitchell), “Boron trifluoride-methanol complex as a non-depurinating
detritylating agent in DNA synthesis,” Nucleic Acids Research,
Vol. 18, No. 17, p. 5321 (1990)
Bergstrom et al. (Bergstrom), “Organoiron-Mediated Alkylation of Phosphite Esters:
Synthesis of (Dicarbonyl)(?5-cyclopentadienyl)iron-Derived Nucleoside
Phosphonate Esters,” J. Org. Chem., Vol. 57, pp. 873-876 (1992)
Gura, “Antisense Has Growing Pains,” Science, Vol. 270, pp. 575-577 (1995)
GROUND OF REJECTION
Claims 1-40 and 59-68 stand rejected under 35 U.S.C. § 112, first
paragraph, as being based on an insufficient disclosure to support or enable the
scope of the claims currently claimed.
We reverse.
2
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