Ex Parte KRUTZIK - Page 5




              Appeal No. 1999-1423                                                                                      
              Application 08/261,639                                                                                    



              35 U.S.C. § 103                                                                                           
                     Claims 48, and 50-60 stand rejected under 35 U.S.C. § 103 over Tzeng and                           
              Berry.                                                                                                    
                     In rejecting claims under 35 U.S.C. § 103, the examiner bears the initial burden                   
              of presenting a prima facie case of obviousness.  See In re Rijckaert, 9 F.3d 1531,                       
              1532, 28 USPQ2d 1955, 1956 (Fed. Cir. 1993).   A prima facie case of obviousness is                       
              established when the teachings from the prior art itself would appear to have suggested                   
              the claimed subject matter to a person of ordinary skill in the art.  In re Bell, 991 F.2d                
              781, 783, 26 USPQ2d 1529, 1531 (Fed. Cir. 1993).  An obviousness analysis requires                        
              that the prior art both suggest the claimed subject matter and reveal a reasonable                        
              expectation of success to one reasonably skilled in the art.   In re Vaeck, 947 F.2d 488,                 
              493, 20 USPQ2d 1438, 1442  (Fed. Cir. 1991).    With this as background, we analyze                       
              the prior art applied by the examiner in the rejection of the claims on appeal.                           
                     The examiner suggests that Tzeng teaches the basic concept of the present                          
              invention.   According to the Examiner, Tzeng describes the second antigen as being                       
              the same as the first antigen and is to be fixed at a second location to capture the                      
              mobile antigen and analyte antibodies.   Tzeng, also, teaches one how to conjugate                        
              BSA and metal sols to the antigen and that such techniques are well known in the art.                     
              Tzeng describes a device that is not only subdivided into reactive regions, but that                      


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