VISSER et al v. HOFVANDER et al - Page 29




          Interference 103,579                                                        

                              Visser’s Claim 24                                       
                    The homologous construct . . . [comprising a full                 
               length potato] . . . GBSS cDNA or genomic DNA in reverse               
               orientation.                                                           
                              Hofvander’s Claim 13                                    
                    A potato plant whose genome comprises the antisense               
               construct . . . [for inhibiting expression of the potato               
               gene which codes for . . . GBSS . . . comprising:                      
                         . . .  a promoter, and                                       
                        . . .  a fragment of a potato gene coding for                
                    . . . GBSS inserted in the antisense direction . . .              
                    selected from the group consisting of SEQ No. 1,                  
                    SEQ ID No. 2 and SEQ ID No. 3].                                   
                              Visser’s Claim 1                                        
                    A . . . potato plant which . . . has a genome                     
               containing at least one gene construct containing a full               
               length . . . GBSS cDNA or genomic DNA sequence coding                  
               for . . . [potato] GBSS in reverse orientation in an                   
               expression cassette . . . , said gene construct giving                 
               rise to tubers containing essentially amylose free starch;             
               wherein said expression cassette comprises in the 5'-3'                
               direction of transcription: an upstream promoter sequence,             
               a base sequence for transcription into mRNA . . . , wherein            
               the coding strand of said base sequence for transcription              
               comprises an inverted sequence of bases complementary                  
               to a run of bases of . . . [potato] GBSS mRNA, wherein                 
               the transcript of said base sequence for transcription                 
               substantially inhibits the expression of . . . [potato]                
               GBSS.                                                                  
               Hofvander and Visser present claims directed to methods of             
          using antisense constructs defined by Hofvander’s Claim 7 and/or            
          Visser’s Claim 15 to transgenically modify the genome of potato             
          plant cells by genetic engineering (Hofvander’s Claim 7) so to              
          grow and regenerate potato plants with “suppress[ed] . . .                  

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