at 7).
38. Dr. Jacob S. Tou testified that he witnessed the
notebook entry of Dr. Huang on 16 September 1993 (Exh. 2026
at ¶¶3-4).
39. According to Huang, NMR analysis confirmed the
structure of the products obtained by Dr. Reitz and Dr. Huang
(Exh. 2011 at 2-10 and Exh. 2020 at ¶7).
40. According to Huang, elemental analysis (Exh.
2013) and mass spectroscopy (Exh. 2012) confirmed the
production and recovery of 3-(4-fluorophenyl)-2-[4-
methylsulfonyl)phenyl] benzofuran (Exh. 2018 at ¶¶7-8; Exh.
2021 at ¶¶2-4; and Exh. 2024 at ¶¶2-5). Dr. Huang testified
that he provided a sample of SC-58394 to Monsanto employee,
Carol M. Koboldt for "biological testing" (Exh. 2018 at ¶9).
41. Subsequent to the Dr. Reitz and Dr. Huang
syntheses, Huang states that other syntheses of compounds
within the scope of the count were undertaken by Searle
employee,
Dr. Timothy Chamberlain at the instruction of Dr. Reitz.
According to Dr. Chamberlain, he was asked by Dr. Reitz to
synthesize several diphenybenzofurans for testing of their
anti-inflammatory activity as COX-2 inhibitors (Exh. 2019 at
¶2).
15
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