Appeal No. 2000-1024 Page 2
Application No. 08/379,551
1. A compound of the formula:
CH2B
H C OCH2P(O)(OR)2
CH3 (IA)
including salts of such compounds, wherein said compound of Formula IA is
substantially free of its enantiomer and wherein B is (a) an unsubstituted purine
moiety, (b) a substituted purine moiety substituted independently at the 2 and/or
6 and/or 8 position by amino, halogen, hydroxy, alkoxy, alkylamino, dialkylamino,
aralkylamino, pyrrolidino, morpholino, piperidino, benzoylamino, azido, mercapto
or alkylthio, or (c) the 8-aza analog thereof, and wherein
B is other than a guanine or 2-amino-6-halopurine;
R is H; and aryl in aralkylamino is a 6-10C aromatic group.
Claims 4, 6, 8, 70, 72, 73, 75, 85, 91, 93 and 94 further limit the
compound of claim 1. Claims 12-19 are drawn to a method of preparing the
compound of claim 1. Claims 45 through 48, 55, 63 and 65 are drawn to specific
compounds that fall within the compound of claim 1.
The examiner relies upon the following references:
Hol [sic] et al. (Holy (US)) 4,808,716 Feb. 28, 1989
Alexander et al. (Alexander) 5,130,427 Jul. 14, 1992
Yu et al. (Yu (US)) 5,302,585 Apr. 12, 1994
Vemishetti et al. (Vemishetti) 5,476,938 Dec. 19, 1995
Webb, II et al. (Webb (US)) 5,650,510 Jul. 22, 1997
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