Ex Parte HOLY et al - Page 6


                  Appeal No.  2000-1024                                                          Page 6                    
                  Application No. 08/379,551                                                                               

                         Holy (EP) was cited for teaching compounds similar to the claimed                                 
                  compounds substituted with different groups, which also have anti-viral activity.                        
                  Starrett was similarly cited for teaching “that for analogous phosphonate                                
                  derivatives as claimed herein, substitution with alkyl- on the purine ring system at                     
                  various ring positions is not a new modification.”  Id. at 6.                                            
                         The examiner concludes:                                                                           
                                Thus it would have been obvious to one skilled in the art at                               
                         the time the instant invention was made to expect instant optical                                 
                         isomers in main claim 1 and claims dependent thereon as well as                                   
                         various 2- and/or 6-substituted purines in independent claims                                     
                         45-48, 55, 63 to be useful against one or more viruses in view of                                 
                         the close structural similarity and equivalency teachings outlined                                
                         above.                                                                                            
                  Id.                                                                                                      
                         The panel would like to initially note that review of the issues on appeal                        
                  was severely hampered by the lack of claim by claim analysis, i.e., the use of a                         
                  shot-gun rejection.  In rejecting claims 1, 4, 6, 8, 45-48, 55, 63, 65, 70, 72, 73,                      
                  75, 85, 91, 93 and 94 over the combination of Holy (US), Webb (EP or US), Yu,                            
                  Starrett and Karrer, the examiner apparently cites Holy (EP) and Starrett for their                      
                  teaching of certain derivatives that are only required in the dependent claims.                          
                  Moreover, the rejection implies that at a minimum, claim 1 is would have been                            
                  obvious over Holy alone.                                                                                 












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