Appeal No. 2001-0288 Page 12
Application No. 08/277,031
Crespi, Sakaki, Yasumori ‘89 and Paolini in view of Wolf, Yasumori ‘87 and
Yabusaki
CLAIMS 6 AND 7
We note that the examiner relies on the teachings of Crespi, Sakaki,
Yasumori ‘89, Paolini, Wolf, Yasumori ‘87 and Yabusaki as applied to claims 1-5,
8, 9, 11, 13 and 14, supra. However, the examiner now emphasizes (Answer,
page 8) that Crespi teaches that “cytochrome P450 1A1 should be recombinantly
expressed among multiply expressed cytochromes P450 in a transformed cell
line to detect carcinogenic metabolites of compounds….” The examiner also
finds (id.) that Eugster “teach that the human cytochrome P450 1A1 may be
successfully expressed in yeast transformants in active form and is involved in
the metabolism of ‘a large group of promutagens present as ubiquitous
environmental pollutants’ but is present at high levels in liver cells only when
induced….” According to the examiner (id.) Ellis “teach that the human
cytochrome P450 IID6 may be successfully expressed in yeast transformants in
active form and that its metabolism has been studied in association with
‘diseases such as cancer and Parkinson’s disease.’” In addition, the examiner
finds (id.) that Bligh “teach that the human cytochrome P450 IIA6 may be
successfully expressed in yeast transformants in active form and may be studied
… in the metabolism of ‘carcinogen activation and deactivation’.” According to
the examiner (Answer, page 9) it would have been obvious to combine Eugster,
Ellis, and Bligh teachings of human P450 cytochromes that are implicated in the
metabolism of carcinogen formation and/or drug metabolism with the
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