Ex Parte HAYASHI et al - Page 15


                 Appeal No.  2001-0288                                                      Page 15                    
                 Application No.  08/277,031                                                                           
                 2B6, 2C8 or 2C18 enzymes should be combined with the 1A2, 2C9, 2E1 and                                
                 3A4 enzymes to make a yeast that is useful in a method for assaying the safety                        
                 of a chemical compound.”  We are not persuaded by appellants’ argument.  As                           
                 discussed supra Crespi disclose yeast expressing cytochrome P450s 1A1, 1A2,                           
                 2A3, 2E1 and 3A4.  When Crespi is combined with the teachings of Sakaki,                              
                 Yasumori ‘89 and Paolini in view of Wolf, Yasumori ‘87 and Yabusaki as in the                         
                 rejection of claim 1, a person of ordinary skill in the art would have had a method                   
                 as set forth in claim 1 wherein the recombinant yeast cells produce 1A1, 1A2,                         
                 2A3, 2C9, 2E1 and 3A4.  Therefore, having found no error in the examiner’s                            
                 rejection of claim 1, we find no error in the examiner’s rejection of claim 7.                        
                 Accordingly, we affirm the rejection of claim 7 under 35 U.S.C. § 103 as being                        
                 unpatentable over Crespi, Sakaki, Yasumori ‘89 and Paolini in view of Wolf,                           
                 Yasumori ‘87 and Yabusaki and further in view of Ellis, Bligh and Eugster.                            
                        No time period for taking any subsequent action in connection with this                        
                 appeal may be extended under 37 CFR § 1.136(a).                                                       
                                                     AFFIRMED                                                          




                                      SHERMAN D. WINTERS                 )                                             
                                      Administrative Patent Judge        )                                             
                                                                         )                                             
                                                                         )                                             
                                                                         ) BOARD OF PATENT                             
                                      TONI R. SCHEINER                   )                                             
                                      Administrative Patent Judge        )   APPEALS AND                               
                                                                         )                                             
                                                                         ) INTERFERENCES                               
                                                                         )                                             





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