Ex Parte CROS et al - Page 7


              Appeal No. 2001-0499                                                     Page 7                       
              Application No. 08/945,731                                                                               

              supported the underlying and ultimate fact findings.”  Id.   What the Federal Circuit                    
              rightfully expects from the Board, the Board expects from the examiner.                                  
                     Under these circumstances, it is appropriate to vacate the rejection and return                   
              the case to the jurisdiction of the examiner to reconsider the patentability of the claims.              
                                                      REMAND                                                           
                     Upon return of the application the examiner should take a step back and                           
              reassess the patentability of the claims.  The reassessment should take place on a                       
              claim-by-claim basis beginning with claim 3.  If the examiner believes that claim 3 is                   
              unpatentable on the basis of Itoh and/or other relevant prior art, he should state the                   
              facts and reasons used in support with particularity.                                                    
                     There is other evidence of record which may be relevant in putting Itoh in proper                 
              factual context to the extent it describes the separation of nucleic material.  We refer to              
              European Patent Application No. 0 501 301 A2, Mori, of record.  Mori describes an                        
              electrophoretic gel comprising at least one cross-linked temperature-responsive                          
              polymeric compound having an LCST used to separate nucleic acids.  As described by                       
              Mori, the acrylamide based gels of that reference are used to absorb nucleic acids at                    
              low temperatures and release the absorbed material at high temperatures.  See, e.g.,                     
              column 6, lines 31-54.  This information may provide evidence that Itoh’s disclosure that                
              gel polymers absorb at a low temperature and release at a high temperature does apply                    
              to nucleic acids and thus provides an answer to appellants’ argument that Itoh is to be                  
              read restrictively as only teaching absorbing nucleic acids at high temperature and                      
              releasing at low temperatures.                                                                           







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