Ex Parte CROS et al - Page 8


              Appeal No. 2001-0499                                                     Page 8                       
              Application No. 08/945,731                                                                               

                     To the extent Itoh and other relevant references teach that absorption and                        
              release of valuable substances using LCST polymers depends on temperature, pH and                        
              ionic strength1 but do not specifically teach the specific parameters required by the                    
              claims on appeal, the examiner should determine if such parameters are result effective                  
              variables.  If so, optimization of such values may have been obvious.  In re Boesch, 617                 
              F.2d 272, 276, 205 USPQ 215, 219 (CCPA 1980).                                                            
                                             FUTURE PROCEEDINGS                                                        
                     We state that we are not authorizing a supplemental examiner’s answer under 37                    
              CFR § 1.193(b)(1).                                                                                       

                                              VACATED; REMANDED                                                        





                                                                             )                                         
                                   William F. Smith                         )                                         
                                   Administrative Patent Judge               )                                         
                                                                             )                                         
                                                                             )                                         
                                                                             ) BOARD OF PATENT                         
                                   Toni R. Scheiner                         )                                         
                                   Administrative Patent Judge               )   APPEALS AND                           
                                                                             )                                         
                                                                             ) INTERFERENCES                           
                                                                             )                                         
                                   Lora M. Green                            )                                         
                                   Administrative Patent Judge               )                                         

              ELD                                                                                                      
                                                                                                                       
              1  See Hoffman, column 1, lines 25-39 (LCST polymers undergo phase separation in response to change      
              in solution pH, ionic strength or temperature.).                                                         





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