Appeal No. 2001-1485
Application No. 08/532,211
REPRESENTATIVE CLAIM
Claim 1 is representative of the claims on appeal and reads
as follows:
1. A method of treating a solution of antibodies which may
have virus activity, the method comprising:
a) contacting the solution with a trialkylphosphate
and a detergent under conditions sufficient to
substantially reduce any virus activity and resulting in
an increased level of anticomplement activity; and
b) then incubating the solution of step a) under
conditions of controlled time, pH, temperature, and
ionic strength, such that the increased anticomplement
activity of the solution is reduced to an acceptable
level suitable for intravenous administration.
The References
In rejecting the claims under 35 U.S.C. § 103(a) the examiner
relies upon the following references:
Tenold (Tenold) 4,396,608 Aug. 02, 1983
Neurath et al. (Neurath) 4,540,573 Sep. 10, 1985
Mitra et al. (Mitra) 4,762,714 Aug. 09, 1988
Joy Yang, Y.H. et al., “Antibody Fc Functioning Activity of
Intravenous Immunoglobulin Preparations Treated with Solvent-
Detergent for Virus Inactivation,” Vox Sang, 1994; 67:337-344 (Joy
Yang).
The Rejections
Claims 1-24 stand rejected under 35 U.S.C.§ 103(a) as being
unpatentable over Tenold in view of Neurath, Mitra, and Joy Yang.
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