Ex Parte GOLDBERG et al - Page 2


                 Appeal No.  2003-0837                                               Page ~ PAGE ~2~                     
                 Application No.  09/078,531                                                                             
                        The references relied upon by the examiner are:                                                  
                 Nevo et al. (Nevo)                  4,642,120                  Feb. 10, 1987                           
                 Itay                              5,053,050                  Oct. 1, 1991                            
                 Bruder et al. (Bruder)              5,736,396                  Apr. 7, 1998                            
                 Grande et al. (Grande)              5,906,934                  May 25, 1999                            
                 Pettipher et al. (Pettipher), “Interleukin 1 induces leukocyte infiltration and                         
                 cartilage proteoglycan degradation in the synovial joint,” Proc. Natl. Acad. Sci.,                      
                 Vol. 83, pp. 8749-53 (1986)                                                                             
                 Joyce et al. (Joyce), “Transforming Growth Factor-b and the Initiation of                               
                 Chondrogenesis and Osteogenesis in the Rat Femur,” J. Cell Biology, Vol. 110,                           
                 pp. 2195-207 (1990)                                                                                     
                                             GROUNDS OF REJECTION                                                        
                        Claims 33-35, 40, 41, 43, 44, 47-49, 50 and 51 stand rejected under 35                           
                 U.S.C. § 102(e) as being anticipated by or, in the alternative, under 35 U.S.C.                         
                 § 103 as being obvious over Grande.                                                                     
                        Claims 42, 45 and 46 stand rejected under 35 U.S.C. 102(e) as                                    
                 anticipated by or, in the alternative, under 35 U.S.C. 103 as obvious over                              
                 Grande.                                                                                                 
                        Claims 36 and 37 stand rejected under 35 U.S.C. § 103 as being                                   
                 unpatentable over Grande in view of Joyce and Bruder.                                                   
                        Claim 38 is rejected under 35 U.S.C. § 103 as being unpatentable over                            
                 Grande in view of Bruder and Pettipher.                                                                 
                        Claim 39 is rejected under 35 U.S.C. § 103 as being unpatentable over                            
                 Grande in view of Nevo and Itay.                                                                        
                        We reverse.                                                                                      










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