Ex Parte MORTENSEN et al - Page 1


                           The opinion in support of the decision being entered today was not written                 
                                  for publication and is not binding precedent of the Board.                          
                                                                                      Paper No. 28                    
                        UNITED STATES PATENT AND TRADEMARK OFFICE                                                     
                                                    __________                                                        
                              BEFORE THE BOARD OF PATENT APPEALS                                                      
                                            AND INTERFERENCES                                                         
                                                    __________                                                        
                     Ex parte UFFE MORTENSEN, KJELD OLESEN, HENNING STENNICKE,                                        
                                  STEEN B. SORENSEN, and KLAUS BREDDAM                                                
                                                    __________                                                        
                                               Appeal No. 2003-1307                                                   
                                             Application No. 09/420,785                                               
                                                    __________                                                        
                                                     ON BRIEF                                                         
                                                    __________                                                        
                 Before SCHEINER, ADAMS, and MILLS, Administrative Patent Judges.                                     
                 ADAMS, Administrative Patent Judge.                                                                  
                                              DECISION ON APPEAL                                                      
                        This is a decision on the appeal under 35 U.S.C. § 134 from the                               
                 examiner’s final rejection of claims 24 and 25, which are all the claims pending in                  
                 the application.                                                                                     
                        Claims 24 and 25 are reproduced below:                                                        
                        24. A modified carboxypeptidase Y, comprising                                                 
                               a substituted amino acid residue in at least one of positions N241                     
                            and L245, wherein the substituted amino acid residue has a                                
                            negatively charged side chain, and                                                        
                               substitutions L178S and M398L,                                                         
                               wherein the modified carboxypeptidase Y is derived from the                            
                            peptide having the sequence of SEQ ID NO: 4.                                              
                        25. A method for transamidating a peptide substrate having a P1 amino                         
                            acid residue with a positively charged side chain and a P3 amino acid                     
                            residue with a positively charged side chain, the method comprising:                      






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