Ex Parte Pugliese - Page 15



          Appeal No. 2005-0545                                                         
          Application No. 09/989,019                                                   

          accumulation of fat when administered orally or topically with               
          suitable solubilizing and emulsifying agents for the elected form of         
          delivery.  See, for example, Soudant, col. 3, l. 49, col. 4, 64, and         
          Examples 1-8; Koulbanis, col. 2, l. 67, to col. 3, l. 54, and                
          Examples III-VI; Majeed, col. 4, l. 47-49; and Sekiya, col. 2,               
          l. 35-58.                                                                    
               There are more explicit reasons why persons having ordinary             
          skill in the art would have combined agents thought to be active for         
          promoting fat degradation and/or lean body mass, controlling                 
          digestion and absorption of lipids, increasing lipolysis, inhibiting         
          phosphodiesterase activity, promoting slimming, treating obesity and         
          regenerating tissue.  First, certain of the cited prior art                  
          references expressly state that persons having ordinary skill in the         
          art should combine active agents for a variety of reasons.  Soudant          
          teaches persons having ordinary skill in the art to combine                  
          lipolytic agents selected from a group including “growth factors             
          . . . xanthines . . . [and] carnitine . . .” (Soudant, col. 2,               
          l. 27-42).  Soudant explains that certain slimming agents, for               
          example, the phosphodiesterase-inhibiting xanthine, caffeine, cannot         
          be used in high concentration (Soudant, col. 2, l. 15-24; emphasis           
          added):                                                                      

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