Ex Parte Pugliese - Page 12



          Appeal No. 2005-0545                                                         
          Application No. 09/989,019                                                   

          (3) an L-carnitine, (4) a xanthine such as theophylline,                     
          theophylline salt, caffeine, or theobromine, (5) Coleus Forskohli            
          plant extract, and (6) solubilizing and (7) emulsifying agents               
          useful in formulating oil-in-water emulsions therewith for topical           
          treatment of localized fat accumulation, cellulite and cellulitis            
          associated therewith.  The prior art need not explicitly direct the          
          combination of each component of the composition with every other or         
          every other combination of components.  It is sufficient that the            
          examiner concluded that persons having ordinary skill in the art             
          reasonably would have expected success in treating localized fat             
          accumulation, cellulite and/or resultant cellulitis using each one           
          or subcombinations of previously disclosed active agents to                  
          establish that a combination of all the previously disclosed active          
          agents prima facie would have been obvious for a common purpose.             
          See In re Kerkhoven, 626 F.2d 846, 850, 205 USPQ 1069, 1072 (CCPA            
          1980):                                                                       
                    It is prima facie obvious to combine two compositions              
               each of which is taught by the prior art to be useful for               
               the same purpose, in order to form a third composition                  
               which is to be used for the very same purpose. . . .                    
               [T]he idea of combining them flows logically from their                 
               having been individually taught in the prior art.                       
               Prima facie obviousness under 35 U.S.C. § 103 has been                  
          established in this case because the prior art teachings, considered         

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