Ex Parte Pugliese - Page 5



          Appeal No. 2005-0545                                                         
          Application No. 09/989,019                                                   

          l. 58-64):                                                                   
                    A still further object of the present invention is                 
               a treatment method designed to combat cellulitis and local              
               fat overload and to improve the aesthetic appearance of a               
               person, characterized by the application to the skin or                 
               oral administration of a composition containing at least                
               one . . . lipolytic active principle.                                   
          Soudant instructs (Soudant, col. 2, l. 3-7):                                 
                    Topical application of an anticellulitic agent may                 
               erase local accumulation of fat by lipolytic action.                    
               The best-known and most widespread method of stimulating                
               lipolysis is by inhibiting phosphodiesterase to prevent                 
               or at least limit the rate of cyclic AMP breakdown.                     
               Thus, absent evidence sufficient to establish that the                  
          invention of Claim 8 is patentably distinct from the invention of            
          Claims 1-7 and 9-11, the patentability of the method of treating             
          cellulitis of Claim 8 by topical application of a formulation of             
          Claims 1-7 and 9-11 reasonably appears to stand or fall with the             
          patentability of formulation Claims 1-7 and 9-11, stated as useful           
          for topical application to the skin of a woman evincing the cosmetic         
          condition called cellulite, in view of the combined prior art                
          teachings.  One or more of the applied prior art references teaches          
          that at least one of the components of the rejected formulation is a         
          phosphodiesterase inhibitor and lipolytic.  Thus, persons having             
          ordinary skill in the art would reasonably have expected that such           
          component could be topically applied to the skin to combat                   

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