Appeal No. 94-0591
Application 07/755,610
have been implicated in the in vivo biosynthesis of
biologically active prostaglandins. The preferred oils
possess an unsaturated fatty acid to saturated fatty
acid ratio of from 10:1 [to] about 5:1. Preferred
vegetable oils include primrose oil, safflower oil,
sunflower oil, sesame oil, cottonseed oil, etc.
B. Wruble
Wruble describes stable oil-in-water emulsions for oral
administration comprising an edible unsaturated oil and
sitosterol (Wruble, col. 1, lines 11-20). According to Wruble
(Wruble, col. 1, l. 56-61):
In contradistinction to other preparations containing
an edible unsaturated oil and sitosterol, it was found that
the present preparation possesses unexpected stability
and palatability. It was found that averting contact
in the final product between the sitosterol and the oil
provides a superior product. Averting said contact is
accomplished by preparing separately an emulsion of the
oil and an aqueous dispersion of the sitosterol, preferably
utilizing protective colloidal materials and emulsifiers.
With respect to component proportions, Wruble teaches
(Wruble, col. 2, l. 31-36):
The amount of the [edible unsaturated] oil can vary
from about 1 to about 35 percent by volume of the
preparation, with from 22 to about 33 percent preferred.
The amount of sitosterol can vary from about 1 to about
17 percent weight/volume, with from about 10 to about
15 percent preferred.
Wruble defines the term edible unsaturated oils as (Wruble,
col. 2, l. 5-19; emphasis added):
. . . those edible oils containing unsaturated fatty acids.
The unsaturated fatty acids include, for example, oleic
acid (1 double bond), linoleic acid (2 double bonds),
linolenic acid (3 double bonds), moroctic acid (4 double
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