Ex parte BOUFFARD et al. - Page 10




          Appeal No. 95-0976                                                          
          Application No. 07/936,558                                                  


          a product claim which is broader than the single compound                   
          whose antimycotic activity is exhibited in the specification.               
               Assuming arguendo that the examiner had established a                  
          prima facie case to reject this claim, the examiner fails to                
          adequately rebut the position taken by appellants.  The data                
          presented in the specification on pages 25-29 exhibits                      
          antibiotic activity in vivo against one strain of yeast and                 
          against Pneumocystis carinii.   However the antibiotic                      
          activity of one of the claimed compounds against several                    
          strains are shown in vitro in this section of the                           
          specification.  Having shown by animal testing the                          
          effectiveness of a compound which exhibited antibiotic                      
          properties both in vitro and in vivo, the appellants' position              
          is that an adequate correlation between in vitro test data and              
          in vivo test data has been established.  The examiner                       
          reiterates that one example is inadequate to support many but               
          does not give any reasons why the correlation between in vitro              
          and in vivo has not been established by the data submitted in               
          the specification.                                                          



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