Appeal No. 1996-2308
Application 08/179,008
APPENDIX
1. A process for
productin g a chiral compound
of the formula
wherein
R is phenyl, W-substituted phenyl, naphthyl, W-
substituted naphthyl, benzodioxolyl, heteroaryl, W-substituted
heteroaryl, benzofused heteroaryl and W-substituted benzofused
heteroaryl, wherein heteroaryl is selected from the group
consisting of pyrrolyl, pyridinyl, pyrimidinyl, pyrazinyl,
triazinyl, imidazolyl, thiazolyl, pyrazolyl, thienyl, oxazolyl
and furnayl, and for nitrogen-containing heteroaryls, the N-
oxides thereof;
1 2
R and R are independently selected from H or R;
W is 1 to 3 substituents independently selected from the
group consisting of lower alkyl, hydroxy lower alkyl, lower
alkoxy, alkoxyalkyl, alkoxyalkoxy, alkoxycarbonylalkoxy,
(lower alkoxyimino)-lower alkyl, lower alkanedioyl, lower
alkyl lower alkanedioyl, allyloxy,
3 3
-CF , -OCF , benzyl, R -benzyl, benzyloxy, R -benzyloxy,3 3
3 4 5
phenoxy, R -phenoxy, dioxolanyl, NO , NR R (lower alkyl)-,
3 2
4 5 6 6
NR R (lower alkoxy)-, OH, halogeno, -NHC(O)OR , -NHC(O)R ,
7 7 4
R O SNH-, (R O S) N-, -S(O) NH , -S(O) R , tert-butyldimethyl-2 2 2 2 2 0-2
silyloxymethyl,
11
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