Appeal No. 1996-2308
Application 08/179,008
R is -O-, -CH -, -NH-9 2 or -N
(lower alkyl)-;
R is H, lower alkyl,10 phenyl
lower alkyl or -C(O)R ;11
R is H, lower alkyl,11 phenyl
or phenyl lower alkyl;
provided that when A is a
bond, R is not H, and1 provid
ed that when R is W-substituted phenyl, W is not p-halogeno;1
comprising cyclizing a hydroxyamide of the formula
1 2
wherein D, A, R , R and R are as defined above, by
treating with:
(ii) a di- or tri-chlorobenzoyl chloride, an aqueous
solution of a base and a phase transfer catalyst; or
(iii) a di- or tri-chlorobenzoyl chloride, an aqueous
solution of a base and a phase transfer catalyst, isolating
the resulting di- or tri-chlorobenzoate intermediate, then
treating the intermediate with an aqueous solution of a base
and a phase transfer catalyst; or
(v) a di- or tri-chlorobenzoyl chloride and a metal
hydride.
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