Appeal No. 1996-1959
Application No. 07/946,546
(b) maintaining said reaction mixture for a time period and under
biological reaction conditions sufficient for condensation of said pyruvate
with said acceptor substrate and formation of a compound of Formula V, VI,
VII or VIII.
The Examiner relies on the following references:
Schreiner et al. (Schreiner), “A Convenient Approach to 3-Deoxy-D-glycero-D-
galacto-nonulosonic Acid (KDN), 5-Azido-5-deoxy-KDN and 5-Deoxy-KDN, and
Their 4-Methylumbelliferyl 2a-Glycosides,” Liebigs Ann. Chem. pp. 581-586 (1990)
Schrell et al. (Schrell), “Synthesis of the I-Methyl Ketoside of 5-Amino Neuraminic
Acid Methyl Ester and Its corresponding 5-Myristoyl and 5-Cyclopropanoyl
Derivative,” Liebigs Ann. Chem. pp. 1111-1114 (1990)
Claim 6 stands rejected under 35 U.S.C. § 102(b) as anticipated by
Schreiner.
Claim 6 stands rejected under 35 U.S.C. § 102(b) as anticipated by Schrell.
Claims 3-6, 10-14 and 16 stand rejected under 35 U.S.C. § 103(a) as being
unpatentable over Schreiner in combination with Schrell.
We reverse.
BACKGROUND
Because of the stereoselectivity of enzymes such as aldolases that
participate in the metabolism of carbohydrates, it is extremely difficult to
design and make new carbohydrates that can be used to study carbohydrate
metabolism. There is a need for such synthetic compounds for use as
experimental tools in elucidating the molecular character of the numerous
and varied pathways involved in carbohydrate anabolism and catabolism.
Of particular relevance to the present invention is the sugar,
N-acetylneuraminic acid (NeuAc) or sialic acid. NeuAc is an integral
component of most cells and is believed to play a major role in imparting
electrical charge characteristics to such cells. Further, NeuAc-like
3
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