Ex parte WONG et al. - Page 9





                   Appeal No. 1996-1959                                                                                                
                   Application No. 07/946,546                                                                                          

                           along with the process for preparing these ketoaldonic acid compounds                                       
                           because to modify the conventional ketoaldonic acid compounds shown by                                      
                           Schreiner et al and Schrell et al through dehydrogenation in order to obtain                                
                           the desired compounds claimed was suggested earlier since Schreiner et al                                   
                           teach that comparison of the rate of hydrogenation in ketoaldonic isomers                                   
                           was previously known in this art and the Schrell et al teaching implies that the                            
                           dehydrogenated form of the ketoaldonic compounds were also known in this                                    
                           art.                                                                                                        
                   Answer, pages 4-6.                                                                                                  
                   The Examiner does not explain, however, why the method steps of the references                                      
                   are considered “comparable” to the methods of the present claims.  It appears that                                  
                   this rejection stems from the Examiner’s unwavering (and incorrect) position that the                               
                   compound illustrated by Schreiner and Schrell (designated                                                           
                   5e and 3, respectively) is merely an acid form of the compound of Formula VIII                                      
                   (Claim 6).  That position is incorrect, for the reasons already discussed.  Further, the                            
                   Examiner does not explain how the combined teachings of the references would                                        
                   have led the ordinary artisan to the specific compounds of claims 3-6 and 16, but                                   
                   simply opines that Schrell teaches compounds that are “analogous” to those of the                                   
                   present claims (Answer, first complete sentence, page 5 and the sentence bridging                                   
                   pages 4 and 5 of the Supplemental Answer).                                                                          
                           With respect to method claims 10-14, the Examiner does not point to any                                     
                   portion or portions of the cited references disclosing or suggesting  the limitations of                            
                   those claims.  Neither Schreiner nor Schrell teaches enzymatic (biochemical)                                        

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