Ex parte MISHIKAWA et al. - Page 2




              Appeal No. 1998-1245                                                                                      
              Application No. 08/111,831                                                                                

                     10.    A method for treating psychosis, comprising administering an effective                      
              dosage of at least one lipoxygenase metabolite of docosahexaenoic acid or derivative                      
              thereof.                                                                                                  
                     11.    The method according to Claim 10, wherein the lipoxygenase metabolite or                    
              derivative thereof is selected from the group consisting of 14-hydroxydocosahexaenoic                     
              acid, ethyl 14-hydroxydocosahexaenoate, 7-hydroxydocosahexaenoic acid or ethyl 7-                         
              hydroxydocosahexaenoate.                                                                                  
                     12.    A method for treating psychosis, comprising administering an effective                      
              dosage of at least one P450 dehydrogenase metabolite of docosahexaenoic acid or                           
              derivative thereof.                                                                                       
                     13. The method according to Claim 12, wherein the P450 dehydrogenase                               
              metabolite or derivative thereof is selected from the group consisting of 7, 8-                           
              epoxydocosapentaenoic acid or ethyl 7, 8-epoxydocosapentaenoate.                                          
                     14.    A method for treating psychosis, comprising administering an effective                      
              dosage of a composition consisting essentially of a phospholipid or triglyceride of                       
              docosahexaenoic acid.                                                                                     
                     The references relied upon by the examiner are:                                                    
              Kimura et al. (Kimura I), “Use of docosahexaenoic acid for improving brain function,”                     
              Chemical Abstracts, Abstract No. 112:191978p (1990)                                                       
              Horrobin et al (Horrobin), “Essential fatty acid composition for treating schizophrenia and               
              inflammatory skin disorders,” Chemical Abstracts, Abstract No. 113:158684n (1990)                         
              Kimura et al. (Kimura II), “Pharmaceutical and food compositions containing                               
              docosahexaenoic acid derivatives for improvement of brain functions,” Chemical                            
              Abstracts, Abstract No. 113:71343b (1990)                                                                 
              Goodman and Gilman's (Goodman and Gilman's), The Pharmacological Basis of                                 
              Therapeutics, (6th Ed.), page 12 (1980)                                                                   
              VanRollins et al. (VanRollins I), "Oxidation of docosahexaenoic acid by rat liver                         
              microsomes," HCAPLUS, Abstract No. 1984:41994 (1984)                                                      


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