Ex parte MISHIKAWA et al. - Page 3



              Appeal No. 1998-1245                                                                                      
              Application No. 08/111,831                                                                                

              VanRollins et al. (VanRollins II), "Synthesis of epoxide and vicinal diol regioisomers from               
              docosahexaenoate methy esters," HCAPLUS, Abstract No. 1989:457336 (1989)                                  
                                                Grounds of Rejection                                                    

                     Claims 8 - 9 stand rejected under 35 U.S.C. § 103.  As evidence of obviousness,                    
              the examiner relies upon Kimura I.                                                                        
                     Claims 10 - 13 stand rejected under 35 U.S.C. § 103.  As evidence of obviousness,                  
              the examiner relies upon Horrobin and Kimura I.                                                           
                     Claim 14 stands rejected under 35 U.S.C. § 103.  As evidence of obviousness, the                   
              examiner relies upon Horrobin and Kimura II.                                                              
                     We reverse for the reasons set forth herein.                                                       
                                                     Discussion                                                         

                                                     Background                                                         
                     The rejections of the claims on appeal, in their present form, were presented for the              
              first time in the Examiner's Answer of March 25, 1996 (Paper No. 15) and were                             
              designated as new grounds of rejection.  The examiner has relied on three abstracts                       
              published in Chemical Abstracts as evidence in support of these rejections.  The examiner                 
              has, additionally, cited and apparently relies on, for the first time in the Supplemental                 
              Examiner's Answer of March 17, 1997 (Paper No. 19) two abstracts of separate articles                     
              by VanRollins et al. and a portion from Goodman and Gilman's.   In the response filed                     
              September 25, 1995 (Paper No. 10) appellants urge that "Horrobin (U.S. Patent No.                         
              5,120,760)-- describes in more detail the technology disclosed in Chemical Abstract                       
              '684."  The U.S. Patent relies on the United Kingdom patent application 88/13766 for                      
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