Ex parte MISHIKAWA et al. - Page 5




              Appeal No. 1998-1245                                                                                      
              Application No. 08/111,831                                                                                

              issues raised by this appeal to the quantum of evidence provided by the specific abstracts                
              relied on by the examiner.                                                                                
                                       The rejections under 35 U.S.C. § 103                                             

                     Claims 8 - 9  stand rejected under 35 U.S.C. § 103 as being obvious over Kimura I.                 
              The examiner urges that this abstract "teaches that ethyl esters of docosahexaenoic acid                  
              (DHA) and DHA itself are known in compositions." (Answer, page 3).   The examiner                         
              acknowledges that the claims are directed to "particular ethyl esters of DHA which are                    
              metabolites of DHA" (Id.) but urges that "one of ordinary skill would have been motivated to              
              employ any particular ethyl ester in a composition since these compounds are known                        
              broadly in compositions, as is the parent compound, DHA, which results in formation of the                
              instant metabolites on administration to a host."  The examiner addresses claim 9 by                      
              stating that "[t]he pentanoic acid metabolites are also obvious from the prior art since they             
              differ from the hexanoic acid patent, DHA, by only one double bond in the carbon chain."                  
              (Answer, sentence bridging pages 3-4).                                                                    
                     In rejecting claims 10 - 13 under 35 U.S.C. § 103 as unpatentable over Horrobin                    
              and Kimura II the examiner states that Horrobin "teaches that DHA is known in                             
              compositions and methods for the treatment of psychosis" and differs from the claims "in                  
              that they are drawn to methods employing particular metabolites of DHA." (Answer, page                    
              4).  The examiner urges that Kimura II "teaches that DHA metabolites encompassed by the                   
              claims are known to have pharmacological activity." (Id.).  The examiner concludes that                   

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