Ex Parte Aleles et al - Page 7



             Appeal No. 2006-2248                                                                               
             Application No. 10/158,618                                                                         

             irritating ingredient, thus increasing the amount of its irritation-producing effects.             
             Thus, glycerin should be present in the composition in a low penetration-enhancing                 
             effective amount (col. 7, lines 55-65).                                                            
                          13. A branched-chain fatty alcohol ester such as octyl hydroxy                        
             stearate may also contribute to the mildness of the compositions of this invention.                
             Other branched-chain fatty esters may be useful in mitigating the irritating effects               
             of the compositions of this invention (col. 8, lines 7-11).                                        
                          14. Preferably, the inclusion of irritating compounds should be                       
             avoided.  For example, butylene glycol is potentially irritating and may cause                     
             additional irritation in the type of formulations of this invention.  Other potentially            
             irritating compounds include soaps, amine-based compounds, surfactants, certain                    
             sunscreen active ingredients and compounds which cause the pH of the                               
             composition to become either extremely acidic or extremely basic (col. 7, line                     
             66, to col. 8, line 6).                                                                            
                          15. As shown herein at Appendix 6, Example 11 (col. 14, lines 25-                     
             54) is the closest disclosed cosmetic composition to the composition claimed in                    




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