Ex Parte Katz et al - Page 2

                 Appeal No. 2007-0054                                                                                    
                 Application No. 08/846,722                                                                              

                 white blood cells) to kill invading bacteria and in response to foreign                                 
                 bodies.”  (Id. at 1.)  “These active oxygen species can injure cells.”  (Id. at                         
                 2.)  “Antioxidants have been shown to inhibit damage associated with active                             
                 oxygen species.”  (Id. at 3.)  Hydrogen peroxide is an example of an active                             
                 oxygen species.  (Id. at 13.)                                                                           
                        The specification describes “a method for treating the disease state in                          
                 mammals caused by mammalian nasal and sinus cells involved in the                                       
                 inflammatory response.”  (Id. at 11.)  The method “comprises:  contacting                               
                 the mammalian nasal and sinus cells participating in the inflammatory                                   
                 response with an inflammatory mediator; wherein the inflammatory                                        
                 mediator is present in an amount capable of reducing the undesired                                      
                 inflammatory response and is an antioxidant.”  (Id.)  “Typical diseases                                 
                 treatable by the present . . . method include but are not limited to rhinitis,                          
                 eosinophilia syndrome, sinusitis and the like.”  (Id. at 18.)                                           
                        The specification states that the preferred inflammatory mediator is                             
                 pyruvate or a pyruvate precursor.  “A precursor is a substance from which                               
                 another substance is formed and . . . also includes salts.”  (Id. at 16.)                               
                                                    DISCUSSION                                                           
                 1.  CLAIMS                                                                                              
                        Claims 1-6, 8-18, and 27-31 are on appeal.  Claims 19-26 are also                                
                 pending but have been withdrawn from consideration by the Examiner.                                     
                        For each rejection, the claims have been argued as a group.  Thus, the                           
                 claims of each rejection stand or fall together.  We will focus on one claim                            
                 from each rejection -- claims 1, 18, and 27, which are representative and                               
                 read as follows:                                                                                        


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