Ex Parte Lee - Page 2

                Appeal 2007-1033                                                                               
                Application 10/091,061                                                                         

                amount of:  (1) at least one anti-proliferative agent and (2) a compound of                    
                formula I” (Spec. 2-3).  A preferred compound of Formula I is Compound 1:                      







                (id. at 17).  “Suitable anti-proliferative agents . . . include . . . capecitabine”            
                (id. at 8-9).                                                                                  
                                                DISCUSSION                                                     
                1.  CLAIMS                                                                                     
                      Claims 117-130 are on appeal.  Claims 101-111 and 113-116 are also                       
                pending and rejected, but the rejections of these claims have not been                         
                appealed.  Thus, the Examiner is entitled to cancel claims 101-111 and 113-                    
                116.  See MPEP § 1215.03.                                                                      
                      We will focus on claim 117, the broadest claim on appeal, which reads:                   
                117. A method of treating cancer in a mammal selected from metastatic                          
                breast cancer, lung cancer, pancreatic cancer, ovarian cancer, prostate                        
                cancer, colon cancer, and/or small cell lung cancer, comprising                                
                administering to the mammal a therapeutically-effective combination of (1)                     
                a dosage unit of capecitabine and (2) a dosage unit of Compound (1), having                    
                the formula,                                                                                   








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