Ex parte AZRIA et al. - Page 2




                 Appeal No. 94-2888                                                                                                                     
                 Application 07/815,457                                                                                                                 


                                                            DECISION ON APPEAL                                                                          
                          This is an appeal from the final rejection of claims 4, 8 through 14, 16, 18                                                  
                 through 26, and 34.  Subsequent to the final Office Action, claim 35 was added.  Thus,                                                 
                 this appeal involves claims 4, 8 through 14, 16, 18 through 26, 34, and 35.                                                            
                          Claim 34 is illustrative of the subject matter on appeal and reads as follows:                                                
                          34.  A liquid pharmaceutical composition comprising 1) a pharmaceutically                                                     
                 acceptable, aqueous liquid nasal carrier; 2) a therapeutically effective amount of a                                                   
                 calcitonin or a pharmaceutically acceptable acid addition salt thereof, wherein said                                                   
                 calcitonin is selected from the group consisting of salmon calcitonin, human calcitonin,                                               
                 porcine calcitonin and 1.7-Asu-eel calcitonin; and 3) about 0.002% to about 0.02% on a                                                 
                 weight per volume basis of a benzalkonium chloride, said composition being in a form                                                   
                 suitable for nasal administration.                                                                                                     

                          The references relied upon by the examiner are:                                                                               
                 Christie et al. (Christie)                   4,241,051                  Dec. 23, 1980                                                  
                 English Translation of                       25197                      Sep. 25, 1981                                                  
                 Japanese Patent Specification                                                                                                          
                 (Teijin)                                                                                                                               
                 Chemical Abstracts No. 214933s, 19812                                                                                                  
                 Ziegler et al., (Ziegler), “Nasal application of calcitonin in Paget’s disease of bone,”                                               
                 Acta Endocrinol. Suppl. (215) 1978, pp. 54-55                                                                                          




                          2The examiner and appellants have relied only upon the abstract, not the                                                      
                 underlying full text document.  For the purposes of this appeal, we, in similar fashion,                                               
                 have considered only the abstract.                                                                                                     
                                                                           2                                                                            





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