Appeal No. 95-0063
Application No. 07/813,868
15. Method for the immobilization of an organic thiol
compound, HS-R, in which R is an organic residue, to a water-
insoluble polymer of non-polypeptide structure exhibiting a
disulfide (-S-S-) group directly bound to a saturated carbon atom
at each of its sulphur atoms, characterized in the steps that:
(i) said polymer is contacted with an oxidation agent in such an
amount and of such a kind that it is capable of transforming
said disulfide group (-S-S-) to an oxidized disulfide group
capable of reacting with thiol groups, whereupon
(ii) the polymer obtained in step (i) exhibiting one or more
oxidized disulfide groups is contacted with the organic
thiol compound HS-R under conditions allowing reaction to
the formation of one -S-S-R group and one -SO (H) group per
n
disulfide oxide group that undergoes the reaction where n is
1 or 2. [Emphasis added.]
25. Method for the immobilization of an organic thiol
compound, HS-R, in which R is an organic residue, to a polymer
exhibiting a disulfide (-S-S-) group directly bound to a
saturated carbon atom at each of its sulphur atoms characterized
in the steps that:
(i) said polymer is contacted with an oxidation agent in such an
amount and of such a kind that it is capable of selectively
transforming said disulfide group (-S-S-) to a -S-SO - group
n
where n is essentially 1 or 2, whereupon
(ii) the polymer obtained in step (i) exhibiting one or more -S-
SO - groups is contacted with the organic thiol compound
n
HS-R under conditions allowing reaction to the formation of
one -S-S-R group and one -SO (H) group per -S-SO - groupn n
that undergoes the reaction,
with the proviso that the polymer carrying the disulfide group is
not a wool textile fiber. [Emphasis added.]
The reference relied on by the examiner is:
J. A. Maclaren et al. (Maclaren), "Partially Oxidised Disulphide
Groups in Oxidised Wool - Reaction with Thiols," JSDC 564-67
(Nov. 1968).
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