Appeal No. 95-2484
Application 07/948,470
43. A method for removing serum amyloid protein from body fluid in a human
mammal suffering from amyloidosis and in need of such treatment, comprising the
sequential steps of:
a) passing said mammal's body fluid containing serum amyloid protein through a
container having a fluid inlet and a fluid outlet and being packed with an adsorbent for a
serum amyloid protein comprising a water-insoluble carrier and dextran sulfate being
immobilized onto said carrier; and
b) returning substantially serum amyloid protein free body fluid to said human
mammal.
46. The method of claim 43, wherein said water-insoluble carrier is made of a
compound containing a hydroxy group.
The references relied on by the examiner are:
Serban et al. (Serban) 4,782,014 Nov. 1, 1988
Lehninger, Biochemistry, Second Edition, Chapter 9, “Enzymes: mechanism, structure
and regulation,” pp. 234-35 (1975)
Rubinow et al. (Rubinow), “Severe Intrahepatic Cholestasis in Primary Amyloidosis: A
Report of Four Cases and a Review of the Literature,” The American Journal of
Medicine, Vol. 64, pp. 937-46 (1978)
Pharmacia Fine Chemicals AB, “Gel Filtration Theory and Practice,” pp. 16 and 20
(1981)
Kato et al. (Kato), “A Therapeutic Trial of Plasmapheresis Combined with DMSO in a
Patient with Primary Amyloidosis,” Jikeikai Medical Journal, Vol. 31, pp. 165-67 (1984)
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